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 * 1) During the study, the rats lost complete control over the ability to regulate whether they were hungry, often eating despite electric shocks. When the obese rats were put on a healthy diet, they refused to eat, starving themselves for two weeks.
 * 2) "The body adapts remarkably well to change
 * 3)   ability to respond to leptin , a hormone that helps regulate eating behavior by controlling how full one feels.
 * 4) "that over-consumption of highly pleasurable food triggers addiction-like neuroadaptive responses in brain reward circuitries, driving the development of compulsive eating